Vacation rentals in Byron

New! MN Comforts The Heart 4Bd/2Bth, 12min to Mayo

Welcome to MN Comforts The Heart! Are you here for work or leisure, or want to feel comforted after a Mayo appts? 12 min to Mayo Clinic, Wifi, work-station, ROKU/Smart TVs, and a fireplace in the family room. We offer a 2nd home feel. Near stores. Split-level, chill, and quiet, thoughtfully designed to cater to your needs, ensuring a comfortable, enjoyable stay. A blend of traditional & modern styling in a tranquil home, with fun opportunities for family & friends. Fully fenced backyard.

XLarge 2 bed 2 bath with rec room near Mayo

Room to spread out! Entire house to yourself, near Mayo Clinic, Single Family Home. Modern 2 bedrooms, 2 baths, kitchen, dining room, beautiful living space and rec room. Amazing quiet location on dead end street near park, excellent restaurants, shopping and Mayo Clinic. Unpack and unwind with choice of shade or sun patio, abundance of walking trails & exercise equipment. All the amenities to cook and launder, we have you taken care of. We look forward to welcoming you to Rochester!

Oasis - Comfort & Serenity (Full house near Mayo)

*Discount for extended stays* Seeking a peaceful respite near Mayo Clinic in Rochester, MN? Look no further than "Oasis"–your ultimate home away from home. We offer 5 beds, 2 baths, & can accommodate up to 8 guests. Recharge in the workout & yoga meditation room, stay connected in the office area, & explore Rochester's attractions. Your dedicated host Peggy, a Mayo employee, will ensure a seamless/enjoyable stay. Book now & experience the perfect blend of comfort & serenity at Oasis.

Near Mayo Family Friendly / 5 beds 2 baths CLEAN

Nestled in the cul-de-sac of Arcon Lane in the northwest side of Rochester, Minnesota, an Airbnb was established in the summer of 2025. It was given a name called Arcon Hollow B&B. Arcon Hollow B&B can be whatever space you’d like it to be for your stay. It can be your peace and quiet space away from the chaos of life, your rest and restore atmosphere to renew your energy, or your home away from home for different reasons that bring you to our beautiful town Rochester, Minnesota.

The Gathering Place Near Mayo Sleeps 10, Dogs

Welcome to The Gathering Place — a peaceful, Superhost-rated home built for families to reconnect when it matters most. Just 4.5 miles from Mayo Clinic, this 2,040 sq ft, 4-bedroom home sleeps up to 10 with room for caregivers and visiting family alike. Rated a Guest Favorite (top 10% on Airbnb) with a 5.0 overall rating, guests consistently praise the hospitality and comfort here. Dog-friendly, fully equipped, and designed for both short stays and longer recoveries.

Downtown Cottages | 5 Blocks From Mayo | No Stairs

Welcome to our Downtown Cottages, Rochester’s First "Tiny Homes" : 3 min drive/10 min walk to the Mayo Clinic Campus. Experience our four charming cottages- Enjoy zero-entry, slab-on-grade living with NO stairs!! Elegantly furnished and fully stocked, each unit also includes off-street parking. Located just 5 blocks from the downtown Mayo Clinic Campus, our cottages offer the perfect blend of comfort and convenience. Book your stay today!

single level Home/ 5 min to Mayo/fenced yard

Peaceful single-level home near Mayo Clinic with comfortable beds, a fully equipped kitchen, fast Wi-Fi, three smart TVs, a private fenced yard with patio, and a variety of indoor and outdoor entertainment options. Conveniently located near the Mayo Clinic campus and Rochester’s main attractions, this rollator-accessible home is ideal for families. We strive to accommodate flexible check-in/check-out arrangements whenever feasible.

The Sierra! Close to Mayo Clinic

Gorgeous Home close to Mayo Clinic. The family room and living include Roku 4K UHD TVs, Foosball, and darts. Free WIFI. Office on Main with great light. Beautiful front porch or patio in the rear. TVs Enjoy luxurious finishes like crown molding, a fireplace in the family room, quartz countertops and a stunning vaulted Primary Ensuite with custom tile work and paneled doors. All of this is conveniently just minutes from downtown!

You’re home! St.Augustine MAYO CLINIC garage!

Time to relax! 2 car Garage Parking (a Minnesota must!) Fast WiFi, smart tv! Washer and Dryer and dishwasher! Clean comfortable home in a great SAFE neighborhood convenient to everything. Recliner! Costco, the best grocery’s stores, bars, restaurants, and movie theaters 1 min away. Minutes from the Mayo Clinic! Quick and easy drive! Check out my other listings to see the 5 Star reviews!

1st Premium Luxury Rooftop Stay w/ Elevator

Experience family fun in this stylish new model home featuring four bedrooms and four bathrooms. Enjoy a rooftop patio, an elevator, and a spacious primary suite with stunning views. The elevator provides easy access to all levels, making grocery trips a breeze from the two-car garage. Conveniently located just 12 minutes from the Mayo Clinic, this home showcases luxurious finishes throughout.

Woodhaven West

Unwind in this charming, pet-friendly haven approximately 2 miles west of St. Mary’s Hospital. Perfect for up to 4 guests, this one-level home offers a peaceful stay in a quiet neighborhood. Enjoy a fully stocked kitchen, washer & dryer, and all the comforts of home. Whether you're visiting for work, medical care, or a relaxing getaway, Woodhaven West is your perfect home base!

Come From Away!

Bring the whole family to this great place with lots of room for fun. An upstairs living room, and large downstairs family room offers plenty of space for everyone. Each common area has a Roku tv so you can watch any of your own streaming services, plus plenty of free options.